Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles
نویسندگان
چکیده
منابع مشابه
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway.
Understanding the molecular basis and target of traditional medicine is critical for drug development. Celastrol, derived from Trypterygium wilfordii Hook F. ("Thunder of God Vine"), a traditional Chinese medicine plant, has been assigned anticancer activities, but its mechanism is not well understood. Here, we investigated whether Celastrol could inhibit angiogenesis-mediated tumor growth and,...
متن کاملQuercetin inhibits angiogenesis-mediated human retinoblastoma growth by targeting vascular endothelial growth factor receptor
Retinoblastoma (RB) is the most common malignant intraocular cancer in teenagers, occurrence of which depends on the mutation of multiple genes. Among all the signaling pathways involved in the oncogenesis of RB, the process of angiogenesis has been demonstrated to be associated with the local invasive growth and metastasis of this cancer type. Quercetin (Que) is a typical flavonoid and has bee...
متن کاملOptimized preparation of celastrol-loaded polymeric nanomicelles using rotatable central composite design and response surface methodology.
Celastrol has been found to be a potent anti-inflammatory and antitumor plant derivative recently. Herein we established an accurate reverse phase HPLC (RP-HPLC) determination method of celastrol, and prepared an effective nanoscale drug delivery system from the optimized formulations of celastrol-loaded carboxyl functioned poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene ...
متن کاملAngiogenesis in Retinoblastoma
Dans certains cancers, un rapport direct a 6t6 6tabli entre la vascularisation de la tumeur et son comportement biologique; cette relation n'a pas 6t6 6tudi& dans le n5tinoblastome. Nous 6tudions le rapport quantitatif entre le comptage des vaisseaux et d'autres d6terminanis du pronostique sur38 yew 6nucl&s pour r6tinoblastome. On a W 6 une analyse B regression multiple pour examiner indbpendam...
متن کاملCelastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats
The aim of the present study was to investigate the inhibitory effects of celastrol-loaded nanomicelles (CNMs) on activated macrophage-induced corneal neovascularization (CNV) in rats and cytokine secretion in macrophages. Using an angiogenesis assay in vitro, we detected the effects of CNMs on human umbilical vein endothelial cell (HUVEC) migration and invasion. In addition, the expression lev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Delivery
سال: 2020
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2020.1730522